Chapter 6 Incidence of retinoblastoma in Dutch children conceived by in vitro fertilization
نویسندگان
چکیده
Background In 2003, we reported an increased risk of retinoblastoma in children conceived by in vitro fertilization (IVF) between 1995 to 2002. However, population-based studies among children conceived by IVF did not find an elevated risk of retinoblastoma. Methods From nationwide estimates of numbers of live births conceived by IVF (n = 40,330), we estimated the expected numbers of retinoblastoma patients conceived by IVF in the period 1995-2007. The actual observed number of retinoblastoma diagnoses in children conceived by IVF was obtained by questionnaires sent to the parents of retinoblastoma patients diagnosed between 1995-2005. For non-responders and patients diagnosed after 2005, information was available through the medical files, in which information on fertility treatments of retinoblastoma patients is routinely recorded since 2000. The relative risk (RR) of retinoblastoma among children conceived by IVF was calculated for the total study period (1995-2007) and for the expanded study period (2002-2007). Results Of all eligible retinoblastoma patients (n = 162) diagnosed in the period 1995-2007, 7 retinoblastoma patients were conceived by IVF. In the total study period (1995-2007) the risk was statistically significantly elevated (RR = 2.54, 95% CI = 1.02-5.23). In the expanded study period (2002-2007), no significantly elevated risk (RR = 1.29, 95% CI = 0.16-4.66) was found. Conclusion We found a statistically significantly increased risk of retinoblastoma in children conceived by IVF in the period 1995-2007. However, the increased risk in the total study period was mostly based on the much stronger risk increase observed in our previous report for the period 1995 to 2002. Caution and awareness on the one hand and avoiding unnecessary worries on the other hand are important at this stage of our knowledge.
منابع مشابه
Incidence of Retinoblastoma in Dutch Children Conceived by in Vitro Fertilization. an Expanded Study
متن کامل
Neonatal outcomes of Offspring Conceived through in Vitro Fertilization
There has been a dramatic rise in the use of Assisted Reproductive Technologies (ART), including In Vitro Fertilization (IVF) throughout the world over the past three decades. Because they represent >1% of the birth cohorts in many developed countries, much attention is being paid to the health and well-being of ART children. Children born after assisted reproductive techniques (ART) have an in...
متن کاملRetinoblastoma in Southwest Iran
Background: Retinoblastoma is the most common embryonic tumor of retina of children. This tumor include 3-4% of all children malignancies during the age range 0-14 years. In this study, we reported the incidence, therapeutic protocols, and treatment outcome of children with RB in South west Iran. Methods: We retrospectively investigated the medical reports clinical and pathological features of...
متن کاملPerinatal complications of assisted reproduction.
The main perinatal complications of assisted reproduction include congenital malformation, chromosomal aberrations, multiple pregnancy, and prematurity. Earlier studies and in vitro fertilization (IVF) registries showed that there was no increased incidence of congenital malformations in children conceived by IVF/intracytoplasmic sperm injection (ICSI). However, a large Australian study has fou...
متن کاملPerinatal Outcomes of Newborn Infants Conceived by Assisted Reproductive Techniques in Royan Institute
Background The outcomes of such pregnancies have been rarely evaluated in our country. A descriptive study was planned to assess the health and condition of neonates conceived with assisted techniques in a one year period. MaterialsAndMethods At Royan Institute, Tehran, 443 women who became pregnant by one of the assisted techniques in vitro fertilization (IVF), intrauterine insemination (IUI) ...
متن کامل